Following an introduction, the Catalogue provides a description of all the works of Armenian provenance known to the author, proceeding chronologically by century. Each entry begins with a summary of the content of the work and a short biography of the author when available. Subsequent European editions or translations of each work are also noted. The work concludes with sections referencing the works of Greek Church Fathers preserved in Armenian and secular literature.

Harrison Gray Otis Dwight (1803-1862) spent thirty years in Constantinople as an American Congregational missionary to the Armenians. He was a graduate of Hamilton College and Andover Theological Seminary. He also wrote such notable works as Christianity Revived in the East, and Christianity in Turkey: A Narrative of the Protestant Reformation in the Armenian Church.