As indicated by the title, this essay gives a historical account of the School of Nisibis from its beginnings in the fourth century until its demise several centuries later. Mixed up in politics, and theological debates, the School finds itself in many difficult predicaments. Despite the troubles, however, the School’s importance cannot be denied as the list of its famous adherents consists of influential teachers and contributors to Eastern theology. It is an informative read for anyone interested in Early Christian thought.